In this workshop, we will discuss how rigor in applied epidemiological methods, combined with qualitative stakeholder involvement, can generate useful and realistic policy insights.
Presenter: Upul
Demonstrates how to operationalize policy emulation using Modified Treatment Policies (MTPs). - Using a dynamic shifts in continuous exposures, providing a methodologically rigorous alternative to static intervention causal frameworks.
Presenter: Sharon
Will focus on identifying the mechanisms through which an exposure translates to an observed outcome. - Demonstrate utilizing causal mediation approaches, decompose total effects to understand structural pathways driving oral health inequalities.
Presenter: Huihua
Will detail the methodological requirements for properly isolating contextual effects, demonstrating how higher-level ecological conditions systematically influence individual-level conditions and individual-level outcomes.
Presenter: Ruby
Will bridge methodological simulation with applied policy formulation. By integrating consumer lived experiences and established stakeholder perspectives, we ensure that the resulting causal models directly map to actionable, culturally relevant policy priorities.
Imagine you are a policymaker with a $1M public health budget.
What kind of evidence would you demand before investing?
A. Associative Evidence “Sugar and dental decay go hand in hand.”
B. Causal Evidence “If we reduce sugar consumption by 20g per day, we avert 15% of all new dental disease.”
You need causal answers, not just correlations.
🔍 Association (Comparing Subgroups)
🎯 Causation (Contrasting the Whole Population)
| Regression CAN tell us: | Regression CANNOT tell us: |
|---|---|
| “People who eat more sugar tend to have more cavities” | “If we reduce sugar, fewer people will get cavities” |
| Variables are related | What would happen under a POLICY |
| Prediction | Causation |
Key message: Regression models isolate robust predictive patterns. However, unmeasured structural confounding ensures these statistical associations frequently fail to translate into causal policy impacts.
Exchangeability To make valid causal claims, the groups we compare must be fundamentally similar across all relevant dimensions before the intervention. We require a true “apples to apples” comparison.
Confounding When structural factors such as baseline income or education differ systematically between groups, exchangeability breaks down. The comparison becomes “apples to oranges,” (direct contrasts are biased).
Causal Evidence: “If we reduce sugar consumption by 20g per day, what is the amount of new dental caries we avert in the population”
A cross-sectional study of 1000 adults:
| Variable | Description |
|---|---|
sugar_consumption |
Daily sugar intake (g/day) |
tooth_decay |
Cavities present? (1=Yes, 0=No) |
age |
Age in years |
sex |
0=Male, 1=Female |
income |
1 (low) → 4 (high) |
education |
1 (low) → 3 (high) |
Overall decay prevalence: 10.4%
Lower-income people consume more sugar AND have more tooth decay — for reasons beyond sugar alone
Fit a logistic regression and read off the odds ratio:
fit_naive <- glm(tooth_decay ~ sugar_consumption +
age + sex +
income + education,
family = binomial, data = dental_data)
broom::tidy(fit_naive, exponentiate = TRUE, conf.int = TRUE) |>
filter(term == "sugar_consumption") |>
select(term, OR = estimate, conf.low, conf.high, p.value) |>
mutate(across(where(is.numeric), \(x) round(x, 3))) |>
knitr::kable()| term | OR | conf.low | conf.high | p.value |
|---|---|---|---|---|
| sugar_consumption | 1.032 | 1.02 | 1.045 | 0 |
“Each additional gram of daily sugar increases the odds of tooth decay by ~3%.”
But this answers: “Among people who happen to differ in sugar intake, how do outcomes compare?”
Not: “If we intervened to change sugar intake, what would happen?”
“For each person, we only see ONE reality: what actually happened. We never see what would have happened if things were different.”
| age | income | sugar_consumption | tooth_decay_observed | What if sugar reduced? |
|---|---|---|---|---|
| 46 | 2 | 42.8 | 0 | ? |
| 38 | 2 | 58.8 | 0 | ? |
| 48 | 1 | 32.0 | 0 | ? |
| 55 | 4 | 43.1 | 0 | ? |
| 43 | 1 | 76.4 | 1 | ? |
| 36 | 4 | 47.0 | 0 | ? |
| 43 | 2 | 48.0 | 0 | ? |
“Modified Treatment Policies let us ESTIMATE these counterfactuals without needing to see them directly.”
Static (bad for continuous): > “Set everyone to exactly 40g sugar” — unrealistic, no data for many people
Modified Treatment Policy (good): > “For people eating more than 50g, reduce by 20g. For others, keep the same.”
Visual:
“This is like a REALISTIC policy — we only ask heavy eaters to cut back, not everyone.”
\[d_1(a_t, h_t) = \begin{cases} a_t - 20 & \text{if } a_t > 50 \\ a_t & \text{otherwise} \end{cases}\]
Defining the Shift in R
# Policy: Reduce sugar by 20 g/day for those consuming > 50 g/day
policy_reduce_20 <- function(data, trt) {
a <- data[[trt]]
ifelse(a > 50, a - 20, a)
}
# Preview what it does to a few observations
dental_data |>
select(sugar_consumption) |>
mutate(
sugar_policy = policy_reduce_20(dental_data, "sugar_consumption")
) |>
slice_sample(n = 7)# A tibble: 7 × 2
sugar_consumption sugar_policy
<dbl> <dbl>
1 75.6 55.6
2 56.6 36.6
3 25.6 25.6
4 61.0 41.0
5 44.5 44.5
6 45.9 45.9
7 68.0 48.0
In R: Observed world estimate
# A tibble: 1 × 4
estimate std.error conf.low conf.high
<dbl> <dbl> <dbl> <dbl>
1 0.104 0.00966 0.0850 0.123
In R: Policiy scenario estimate
# A tibble: 1 × 4
estimate std.error conf.low conf.high
<dbl> <dbl> <dbl> <dbl>
1 0.0756 0.00913 0.0577 0.0935
Absolute causal contrasts
# A tibble: 1 × 4
Policy estimate conf.low conf.high
<chr> <dbl> <dbl> <dbl>
1 Reduce 20g if >50g -0.0283 -0.0392 -0.0174
Relative causal contrasts
# A tibble: 1 × 4
Policy estimate conf.low conf.high
<chr> <dbl> <dbl> <dbl>
1 Reduce 20g if >50g 0.728 0.630 0.825
In the real world: 10.4% (estimate of fit_obs= 0.104) have tooth decay
If we reduced sugar by 20g for heavy eaters: 7.5% (fit_mtp_20 estimate=0.0756) would have tooth decay
That’s a 2.8% point DROP (or 1-0.756 = 0.244 , i.e, 24.4% reduced risk) in tooth decay!
CAUTION: given exchangeability, positivity, & consistancy
| Assumption | Simple explanation |
|---|---|
| Positivity | “The policy is realistic - everyone can actually do it” |
| No hidden factors | “We measured the important factors (income, age, etc.)” |
| No spillover | “Your sugar doesn’t affect my teeth” |
Ask causal questions. Define feasible interventions. Use the right tools.
Key papers
Díaz et al. (2023). Nonparametric Causal Effects Based on Longitudinal Modified Treatment Policies. JASA.
Kennedy (2019). Nonparametric Causal Effects Based on Incremental Propensity Score Interventions. JASA.
Software
All analyses use a simulated dataset for illustration.
IADR 2026 - LMTP for Dental Public Health Research